The main causes behind this issue are different configurations of the system, interference by third-party software, corrupt drivers, etc. If you encounter the same problem if Alt + F4 is not working on Windows 10, then kindly read through this article for the resolution.
It is one of the most used keyboard shortcuts, however, many users report that the combination doesn’t work. The combination of ALT + F4 is useful in shutting down applications and systems.
